Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human) Oryctolagus Cuniculus (rabbit)
TISSUE(S): Reticulocyte
SUBMITTER: Anne Gonzalez de Peredo
LAB HEAD: odile Schiltz
PROVIDER: PXD006081 | Pride | 2018-03-14
REPOSITORIES: Pride
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F080048.dat | Other | |||
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Cayrol Corinne C Duval Anais A Schmitt Pauline P Roga Stephane S Camus Mylène M Stella Alexandre A Burlet-Schiltz Odile O Gonzalez-de-Peredo Anne A Girard Jean-Philippe JP
Nature immunology 20180319 4
Allergic inflammation has crucial roles in allergic diseases such as asthma. It is therefore important to understand why and how the immune system responds to allergens. Here we found that full-length interleukin 33 (IL-33<sub>FL</sub>), an alarmin cytokine with critical roles in type 2 immunity and asthma, functioned as a protease sensor that detected proteolytic activities associated with various environmental allergens across four kingdoms, including fungi, house dust mites, bacteria and poll ...[more]