Proteomics

Dataset Information

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Mass spectrometry analysis of cleavage sites for different protease allergens in human IL-33


ABSTRACT: The cytokine interleukin-33 (IL-33) is an epithelial alarmin with critical roles in allergic inflammation and type 2 immunity. The project aims at the characterization of the direct cleavage of IL-33 by allergen proteases, resulting in its activation, and in the subsequent induction of type 2 cytokine production in group 2 innate lymphoid cells. The present dataset contains mass spectrometry analyses to map the cleavage sites for 9 distinct allergens proteases in the human IL-33 sequence.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human) Oryctolagus Cuniculus (rabbit)

TISSUE(S): Reticulocyte

SUBMITTER: Anne Gonzalez de Peredo  

LAB HEAD: odile Schiltz

PROVIDER: PXD006081 | Pride | 2018-03-14

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F080048.dat Other
F080049.dat Other
F080050.dat Other
F080051.dat Other
F080052.dat Other
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Publications

Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33.

Cayrol Corinne C   Duval Anais A   Schmitt Pauline P   Roga Stephane S   Camus Mylène M   Stella Alexandre A   Burlet-Schiltz Odile O   Gonzalez-de-Peredo Anne A   Girard Jean-Philippe JP  

Nature immunology 20180319 4


Allergic inflammation has crucial roles in allergic diseases such as asthma. It is therefore important to understand why and how the immune system responds to allergens. Here we found that full-length interleukin 33 (IL-33<sub>FL</sub>), an alarmin cytokine with critical roles in type 2 immunity and asthma, functioned as a protease sensor that detected proteolytic activities associated with various environmental allergens across four kingdoms, including fungi, house dust mites, bacteria and poll  ...[more]

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