Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Karin Hansson
LAB HEAD: Peter James
PROVIDER: PXD006429 | Pride | 2019-11-08
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 192 |
Sapir Tamar T Segal Michal M Grigoryan Gayane G Hansson Karin M KM James Peter P Segal Menahem M Reiner Orly O
Frontiers in cellular neuroscience 20190313
Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the current study, we identified 62 high-confident PPT1-binding proteins. These proteins included a self-interaction of PPT1, two V-type ATPases, calcium voltage-gated channels, cytoskeletal proteins and others. Pathway analysis suggested their involvement in ...[more]