Proteomics

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Analysis of single human glomeruli of a patient with NPHS1 mutation - part 2

ABSTRACT: We analyzed the proteome of single human glomeruli obtained by sieving. We compared glomeruli from a patient with NPHS1 mutation with glomeruli from a patient with a tumour nephrectomy (control patient).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Kidney

SUBMITTER: Markus Rinschen  

LAB HEAD: Markus Rinschen

PROVIDER: PXD006522 | Pride | 2018-06-28

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20170421_Q1_AWH_ColID_336_ProjID_540_Benzing_sample01.index Other
20170421_Q1_AWH_ColID_336_ProjID_540_Benzing_sample01.raw Raw
20170421_Q1_AWH_ColID_336_ProjID_540_Benzing_sample02.index Other
20170421_Q1_AWH_ColID_336_ProjID_540_Benzing_sample02.raw Raw
20170421_Q1_AWH_ColID_336_ProjID_540_Benzing_sample03.index Other
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Publications

In diseases of many parenchymatous organs, heterogeneous deterioration of individual functional units determines the clinical prognosis. However, the molecular characterization at the level of such individual subunits remains a technological challenge that needs to be addressed in order to better understand pathological mechanisms. Proteinuric glomerular kidney diseases are frequent and assorted diseases affecting a fraction of glomeruli and their draining tubules to variable extents, and for wh  ...[more]

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