Proteomics

Dataset Information

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Large Cohort Proteomics Profiling of Human Brain Cortex

ABSTRACT: LC-MS/MS profiling of mid frontal or inferior temporal cortex from ROS, MAP and KRONOSII cohorts.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Neural Cell

DISEASE(S): Alzheimer's Disease

SUBMITTER: Matthew Monroe  

LAB HEAD: Vlad Petyuk

PROVIDER: PXD006537 | Pride | 2019-05-13

REPOSITORIES: Pride

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Alz_P01_A01_097_26Apr12_Roc_12-03-15.mgf Mgf
Alz_P01_A01_097_26Apr12_Roc_12-03-15.raw Raw
Alz_P01_A01_097_26Apr12_Roc_12-03-15_msgfplus.mzid.gz Mzid
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Alz_P01_A02_098_26Apr12_Roc_12-03-26.raw Raw
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Publications

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.

Petyuk Vladislav A VA   Chang Rui R   Ramirez-Restrepo Manuel M   Beckmann Noam D ND   Henrion Marc Y R MYR   Piehowski Paul D PD   Zhu Kuixi K   Wang Sven S   Clarke Jennifer J   Huentelman Matthew J MJ   Xie Fang F   Andreev Victor V   Engel Anzhelika A   Guettoche Toumy T   Navarro Loida L   De Jager Philip P   Schneider Julie A JA   Morris Christopher M CM   McKeith Ian G IG   Perry Robert H RH   Lovestone Simon S   Woltjer Randall L RL   Beach Thomas G TG   Sue Lucia I LI   Serrano Geidy E GE   Lieberman Andrew P AP   Albin Roger L RL   Ferrer Isidre I   Mash Deborah C DC   Hulette Christine M CM   Ervin John F JF   Reiman Eric M EM   Hardy John A JA   Bennett David A DA   Schadt Eric E   Smith Richard D RD   Myers Amanda J AJ  

Brain : a journal of neurology 20180901 9

Our hypothesis is that changes in gene and protein expression are crucial to the development of late-onset Alzheimer’s disease. Previously we examined how DNA alleles control downstream expression of RNA transcripts and how those relationships are changed in late-onset Alzheimer’s disease. We have now examined how proteins are incorporated into networks in two separate series and evaluated our outputs in two different cell lines. Our pipeline included the following steps: (i) predict  ...[more]

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