Dataset Information

Pre-histopathological and sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: a multi-omic analysis

ABSTRACT: Like many neurological disorders, Alzheimerâ€™s disease has a sex-biased epidemiological profile, affecting approximately twice as many women as men. The cause of this sex difference has yet to be elucidated. To identify molecular correlates of this sex bias, we investigated molecular pathology in females and males using the 5XFAD genetic mouse model of Alzheimerâ€™s disease. We profiled the transcriptome and proteome of the mouse hippocampus during early stages of disease development (1, 2, and 4 months) with RNA-sequencing and Liquid-chromatography mass spectrometry.

OTHER RELATED OMICS DATASETS IN: GSE97113

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Joseph Bundy

LAB HEAD: Richard S. Nowakowski

PROVIDER: PXD006587 | Pride | 2018-10-10

REPOSITORIES: Pride

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			Action	DRS
	06092015_JLB_10A_Run1.raw	Raw
	06092015_JLB_10A_Run2.raw	Raw
	06092015_JLB_10A_Run3.raw	Raw
	06092015_JLB_10B_Run1.raw	Raw
	06092015_JLB_10B_Run2.raw	Raw

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Publications

Sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi-omic analysis.

Bundy Joseph L JL Vied Cynthia C Badger Crystal C Nowakowski Richard S RS

The Journal of comparative neurology 20181108 2

Alzheimer's disease is a progressive neurodegenerative disorder and the most common form of dementia. Like many neurological disorders, Alzheimer's disease has a sex-biased epidemiological profile, affecting approximately twice as many women as men. The cause of this sex difference has yet to be elucidated. To identify molecular correlates of this sex bias, we investigated molecular pathology in females and males using the 5XFamilial Alzheimer's disease mutations (5XFAD) genetic mouse model of A ...[more]

PMID: 30291623

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