Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Stem Cell, Cell Culture
SUBMITTER: Elisabeth Karg
LAB HEAD: Heinrich Leonhardt
PROVIDER: PXD006593 | Pride | 2017-10-24
REPOSITORIES: Pride
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Journal of molecular biology 20171018 24
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. The E3 ubiquitin ligase ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1) is an essential epigenetic factor that recognizes repressive histone marks as well as hemi-methylated DNA and recruits DNA methyltransferase 1. To explore enzymatic functions of UHRF1 beyond epigenetic regulation, we conducted a comprehensive screen in mouse e ...[more]