Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Placenta
SUBMITTER: cheung wanling
LAB HEAD: Tong Wang
PROVIDER: PXD006654 | Pride | 2017-10-04
REPOSITORIES: Pride
Action | DRS | |||
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20170302_P_DIP_DDA_LIB_1.raw | Raw | |||
20170302_P_DIP_DDA_LIB_2.raw | Raw | |||
20170302_P_DIP_DDA_LIB_3.raw | Raw | |||
20170302_P_DIP_DDA_LIB_4.raw | Raw | |||
20170302_P_DIP_DIA_C087.raw | Raw |
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Zhang Wanling W Chen Xing X Yan Ziqi Z Chen Yang Y Cui Yizhi Y Chen Bingjun B Huang Chujun C Zhang Weiwen W Yin Xingfeng X He Qing-Yu QY He Fang F Wang Tong T
Journal of proteome research 20171017 12
Preeclampsia (PE) is a placenta disease, featured by hypertension, proteinuria, and other multiorgan dysfunctions, and its etiology is unclear. We and others have shown that intensive endoplasmic reticulum (ER) stress and unfolded protein response (UPR) occur in the PE placenta. In this study, we isolated detergent-insoluble proteins (DIPs) from human placenta tissues, which were enriched with protein aggregates, to characterize the placenta UPR in PE. With data-independent acquisition (DIA) mas ...[more]