Quantitative analysis of acetylome reveals the roles of Rpd3 and Sir2 in asexual development, virulence and multiple stress responses in Beauveria bassiana.

ABSTRACT: Lysine acetylation is one of the most prevalent post-translational modifications and has since been found to regulate histone functions and affect chromatin structure and gene expression. Here, we charactered Rpd3, a histone deacetylase of Beauveria bassiana, played important roles in the deacetylation of histone H3 and H4. We unveil the role of Rpd3 in asexual development and show that a ΔRpd3 mutant strain has severe growth defects and is defective in conidiophores and blastospores development. Acetylomic analyses indicated that Rpd3 functions in asexual development and virulence and multiple stress responses via broad genetic pathways in B. bassiana. Therefore, we conclude that BbRpd3 is vital for asexual development, virulence and multiple stress responses in Beauveria bassiana.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Beauveria Bassiana (strain Arsef 2860) (white Muscardine Disease Fungus) (tritirachium Shiotae)

TISSUE(S): Fungal Cell, Fungal Cell Line

SUBMITTER: QING CAI  

LAB HEAD: Mingguang Feng

PROVIDER: PXD006714 | Pride | 2021-08-12

REPOSITORIES: Pride