Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Hela Cell
SUBMITTER: Johan Palmfeldt
LAB HEAD: Johan Palmfeldt
PROVIDER: PXD006788 | Pride | 2018-08-29
REPOSITORIES: Pride
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228_Bin-pCDH-flag1.raw | Raw | |||
229_Bin-hStat-Flag1.raw | Raw | |||
230_Bin-hStat3-NCI.raw | Raw | |||
2909-Bin-cross-1A.raw | Raw | |||
2911-Bin-cross-2A.raw | Raw |
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Liu Bin B Palmfeldt Johan J Lin Lin L Colaço Alexandria A Clemmensen Knut K B KKB Huang Jinrong J Xu Fengping F Liu Xin X Maeda Kenji K Luo Yonglun Y Jäättelä Marja M
Cell research 20180820 10
Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production, cancer cells maintain alkaline intracellular pH that promotes cancer progression by inhibiting apoptosis and increasing glycolysis, cell growth, migration, and invasion. Here we identify signal transducer and activator of transcription-3 (STAT3) as a key factor in the preservation of alkaline cytosol. STAT3 associates with the vacuolar H<sup>+</sup>-ATPase in a c ...[more]