Proteomics

Dataset Information

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In-depth protein profiling of cytology samples in urothelial carcinoma


ABSTRACT: Urine cytologic examination is a widely used primary pathologic screening test in the diagnosis of bladder urothelial carcinoma (BLCA), however the low diagnostic accuracy remains challenging. We conducted high-throughput proteome on ten pairs of BLCA and benign urothelial lesion (BUL) to identify a supportive proteomic marker as an ancillary test in liquid based cytology (LBC).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urinary Bladder

DISEASE(S): Bladder Transitional Cell Carcinoma

SUBMITTER: Dohyun Han  

LAB HEAD: Dohyun Han

PROVIDER: PXD006805 | Pride | 2018-07-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20161111_cytology_15337_1.raw Raw
20161111_cytology_15337_2.raw Raw
20161111_cytology_16342_1.raw Raw
20161111_cytology_16342_2.raw Raw
20161111_cytology_16531_1.raw Raw
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Publications

Quantitative Proteomic Analysis Identifies AHNAK (Neuroblast Differentiation-associated Protein AHNAK) as a Novel Candidate Biomarker for Bladder Urothelial Carcinoma Diagnosis by Liquid-based Cytology.

Lee Hyebin H   Kim Kwangsoo K   Woo Jongmin J   Park Joonho J   Kim Hyeyoon H   Lee Kyung Eun KE   Kim Hyeyeon H   Kim Youngsoo Y   Moon Kyung Chul KC   Kim Ji Young JY   Park In Ae IA   Shim Bo Bae BB   Moon Ji Hye JH   Han Dohyun D   Ryu Han Suk HS  

Molecular & cellular proteomics : MCP 20180627 9


Cytological examination of urine is the most widely used noninvasive pathologic screen for bladder urothelial carcinoma (BLCA); however, inadequate diagnostic accuracy remains a major challenge. We performed mass spectrometry-based proteomic analysis of urine samples of ten patients with BLCA and ten paired patients with benign urothelial lesion (BUL) to identify ancillary proteomic markers for use in liquid-based cytology (LBC). A total of 4,839 proteins were identified and 112 proteins were co  ...[more]

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