Proteomics

Dataset Information

0

Quantitative proteomics of a human fetal ovary development timecourse


ABSTRACT: A quantitative proteomics approach was used to assess protein expression from a time course of human fetal ovarian tissue in comparison to reproductive-aged tissue.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovary

SUBMITTER: Alisha Bothun  

LAB HEAD: Dori C Woods

PROVIDER: PXD006898 | Pride | 2019-05-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
070215D108_1-01.mzid Mzid
070215D108_1-01.mzid_070215D108_1-01.MGF Mzid
070215D108_1.raw Raw
070215D108_2-01.mzid Mzid
070215D108_2-01.mzid_070215D108_2-01.MGF Mzid
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Publications

Quantitative Proteomic Profiling of the Human Ovary from Early to Mid-Gestation Reveals Protein Expression Dynamics of Oogenesis and Folliculogenesis.

Bothun Alisha M AM   Gao Yuanwei Y   Takai Yasushi Y   Ishihara Osamu O   Seki Hiroyuki H   Karger Barry B   Tilly Jonathan L JL   Woods Dori C DC  

Stem cells and development 20180529 11


The in vivo gene networks involved in coordinating human fetal ovarian development remain obscure. In this study, quantitative mass spectrometry was conducted on ovarian tissue collected at key stages during the first two trimesters of human gestational development, confirming the expression profiling data using immunofluorescence, as well as in vitro modeling with human oogonial stem cells (OSCs) and human embryonic stem cells (ESCs). A total of 3,837 proteins were identified in samples spannin  ...[more]

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