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DeltaFBA shotgun Francicella - The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

ABSTRACT: Fructose-1,6-bisphosphate aldolase, a ubiquitous metabolic enzyme with regulatory functions in pathogenic Francisella

INSTRUMENT(S): Q Exactive

ORGANISM(S): Escherichia Coli

SUBMITTER: Chiara guerrera

LAB HEAD: Chiara Guerrera

PROVIDER: PXD006908 | Pride | 2018-11-22

REPOSITORIES: Pride

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			Action	DRS
	20160226_AlCH_DFBA_n1_1_3258.raw	Raw
	20160226_AlCH_DFBA_n1_2_3259.raw	Raw
	20160226_AlCH_DFBA_n1_3_3260.raw	Raw
	20160226_AlCH_DFBA_n2_1_3261.raw	Raw
	20160226_AlCH_DFBA_n2_2_3262.raw	Raw

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Publications

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella.

Ziveri Jason J Tros Fabiola F Guerrera Ida Chiara IC Chhuon Cerina C Audry Mathilde M Dupuis Marion M Barel Monique M Korniotis Sarantis S Fillatreau Simon S Gales Lara L Cahoreau Edern E Charbit Alain A

Nature communications 20171011 1

The enzyme fructose-bisphosphate aldolase occupies a central position in glycolysis and gluconeogenesis pathways. Beyond its housekeeping role in metabolism, fructose-bisphosphate aldolase has been involved in additional functions and is considered as a potential target for drug development against pathogenic bacteria. Here, we address the role of fructose-bisphosphate aldolase in the bacterial pathogen Francisella novicida. We demonstrate that fructose-bisphosphate aldolase is important for bac ...[more]

PMID: 29021545

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