Proteomics

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Escherichia coli msbB-deficient mutant extracellular vesicle proteome

ABSTRACT: Bacteria actively secrete extracellular vesicles (EVs), spherical nano-sized proteolipids into the extracellular milieu. Bacterial EVs have gained wide interests as non-living complex vaccines or delivery vehicles. However, no studies have used bacterial EVs in treating cancer so far. Our results showed remarkable capability of EVs derived from Escherichia coli W3110 msbB-deficient mutant to effectively induce long-term anti-tumor immune responses that can fully eradicate established tumors without notable adverse effects. This anti-tumor effect was IFN-γ-dependent, and we present a comprehensive proteome of E. coli W3110 msbB-deficient EVs to investigate which vesicular components induce the anti-tumor effects.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Escherichia Coli

TISSUE(S): Cell Culture

SUBMITTER: Yong Song Gho  

LAB HEAD: Yong Song Gho

PROVIDER: PXD006912 | Pride | 2018-11-22

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Ecoli_W3110_msbB_EV_1.mzXML Mzxml
Ecoli_W3110_msbB_EV_2.mzXML Mzxml
Ecoli_W3110_msbB_EV_3.mzXML Mzxml
Ecoli_W3110_msbB_EV_4.mzXML Mzxml
Ecoli_W3110_msbB_EV_5.mzXML Mzxml
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Publications

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response.

Kim Oh Youn OY   Park Hyun Taek HT   Dinh Nhung Thi Hong NTH   Choi Seng Jin SJ   Lee Jaewook J   Kim Ji Hyun JH   Lee Seung-Woo SW   Gho Yong Song YS  

Nature communications 20170920 1

Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with outer membrane proteins, to the surroundings. Outer membrane vesicles have gained wide interests as non-living complex vaccines or delivery vehicles. However, no study has used outer membrane vesicles in treating cancer thus far. Here we investigate the potential of bacterial outer membrane vesicles as therapeutic agents to treat cancer via immunotherapy. Our results show remark  ...[more]

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