Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Meningioma
SUBMITTER: Jemma Dunn
LAB HEAD: Clemens Oliver Hanemann
PROVIDER: PXD007044 | Pride | 2019-01-07
REPOSITORIES: pride
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Dunn Jemma J Ferluga Sara S Sharma Vikram V Futschik Matthias M Hilton David A DA Adams Claire L CL Lasonder Edwin E Hanemann C Oliver CO
EBioMedicine 20181226
<h4>Background</h4>Meningioma is the most frequent primary intracranial tumour. Surgical resection remains the main therapeutic option as pharmacological intervention is hampered by poor knowledge of their proteomic signature. There is an urgent need to identify new therapeutic targets and biomarkers of meningioma.<h4>Methods</h4>We performed proteomic profiling of grade I, II and III frozen meningioma specimens and three normal healthy human meninges using LC-MS/MS to analyse global proteins, e ...[more]