Proteomics

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Proteomic analysis of meningioma of different grades identifies potential therapeutic targets and biomarkers


ABSTRACT: Meningiomas are common brain tumours arising from meningeal tissue. Despite the majority of them displaying benign features, they can cause mild to severe morbidity. The current main therapeutic approach is complete tumour resection commonly with adjunct radiation therapy. However, tumour location can hamper complete resection and chemotherapies are ineffective. In this study we aim to elucidate dysregulated pathways in meningioma pathogenesis and identify novel molecular targets by deciphering the proteome and phosphoproteome of different grades of meningiomas. Tumour lysates were collected from grade I, II and III frozemeningioma specimens and three normal healthy human meninges.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Meningioma

SUBMITTER: Jemma Dunn  

LAB HEAD: Clemens Oliver Hanemann

PROVIDER: PXD007044 | Pride | 2019-01-07

REPOSITORIES: pride

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Publications

Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism.

Dunn Jemma J   Ferluga Sara S   Sharma Vikram V   Futschik Matthias M   Hilton David A DA   Adams Claire L CL   Lasonder Edwin E   Hanemann C Oliver CO  

EBioMedicine 20181226


<h4>Background</h4>Meningioma is the most frequent primary intracranial tumour. Surgical resection remains the main therapeutic option as pharmacological intervention is hampered by poor knowledge of their proteomic signature. There is an urgent need to identify new therapeutic targets and biomarkers of meningioma.<h4>Methods</h4>We performed proteomic profiling of grade I, II and III frozen meningioma specimens and three normal healthy human meninges using LC-MS/MS to analyse global proteins, e  ...[more]

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