Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE102823
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Cell Culture, T-lymphocyte
DISEASE(S): Cancer
SUBMITTER: John Koomen
LAB HEAD: Daniel Abate-Daga
PROVIDER: PXD007085 | Pride | 2019-11-07
REPOSITORIES: Pride
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Science signaling 20190212 568
Adoptive transfer of T cells that express a chimeric antigen receptor (CAR) is an approved immunotherapy that may be curative for some hematological cancers. To better understand the therapeutic mechanism of action, we systematically analyzed CAR signaling in human primary T cells by mass spectrometry. When we compared the interactomes and the signaling pathways activated by distinct CAR-T cells that shared the same antigen-binding domain but differed in their intracellular domains and their in ...[more]