Dataset Information
Analysis of the mouse kidney cortex phosphoproteome of VPS34 knockout and control animals
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Kidney
SUBMITTER: 
Markus Rinschen
LAB HEAD: Markus Rinschen
PROVIDER: PXD007093 | Pride | 2024-01-26
REPOSITORIES: Pride
Dataset's files
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Publications
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney.
Science signaling 20221129 762
The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key metabolic organ that controls reabsorption of nutrients such as fatty acids, amino acids, sugars, and proteins. Here, by combining metabolomics, proteomics, and phosphoproteomics analyses with functional and superresolution imaging assays of mice with an inducible deficiency in proximal tubular cells, we revealed that VPS34 contr ...[more]
