Dataset Information

Endogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders

ABSTRACT: Disrupted in schizophrenia 1 (DISC1) has been implicated in contributing to a number of psychiatric diseases and neurodevelopmental phenotypes such as the proliferation and differentiation of neural progenitor cells. While there has been significant effort directed towards understanding the function of DISC1 through the determination of its protein-protein interactions within an in-vitro setting, endogenous interactions involving DISC1 within a cell-type specific setting relevant to neural development remain unclear.

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Brent Wilkinson

LAB HEAD: Marcelo Coba

PROVIDER: PXD007103 | Pride | 2018-07-04

REPOSITORIES: Pride

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Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

Wilkinson Brent B Evgrafov Oleg V OV Zheng DongQing D Hartel Nicolas N Knowles James A JA Graham Nicholas A NA Ichida Justin K JK Coba Marcelo P MP

Biological psychiatry 20180523 4

<h4>Background</h4>Disrupted in schizophrenia 1 (DISC1) has been implicated in a number of psychiatric diseases along with neurodevelopmental phenotypes such as the proliferation and differentiation of neural progenitor cells. While there has been significant effort directed toward understanding the function of DISC1 through the determination of its protein-protein interactions within an in vitro setting, endogenous interactions involving DISC1 within a cell type-specific setting relevant to neu ...[more]

PMID: 29961565

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	Astro_Control_IP_1.msf	Msf
	Astro_Control_IP_1.raw	Raw
	Astro_Control_IP_2.msf	Msf
	Astro_Control_IP_2.raw	Raw
	Astro_DISC1_IP_1.msf	Msf