Dataset Information

Mouse kidney cisplatin TAILS - The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

ABSTRACT: Profiling of proteolytic events mouse kidneys during cisplatin-induced kidney damage. Kidneys from vehicle-treated mice are compared to cisplatin-treated mice and cisplatin treatment in animals preconditioned by hypoxia or calory restriction regimes.

INSTRUMENT(S): maXis

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Pitter Huesgen

LAB HEAD: Pitter Huesgen

PROVIDER: PXD007186 | Pride | 2018-10-29

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	160331KTAILSVCisCR5uL_RA3_01_900.d.zip	Other
	160331KTAILSVCisHP5uL_RA2_01_898.d.zip	Other
	160405KTAILSVCisCR15uL_RA3_01_943.d.zip	Other
	160405KTAILSVCisHP15uL_RA2_01_941.d.zip	Other
	160603PFHKTAILS1-HP-50ST2h_BD5_01_1217.d.zip	Other

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The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Späth Martin R MR Bartram Malte P MP Palacio-Escat Nicolàs N Hoyer K Johanna R KJR Debes Cedric C Demir Fatih F Schroeter Christina B CB Mandel Amrei M AM Grundmann Franziska F Ciarimboli Giuliano G Beyer Andreas A Kizhakkedathu Jayachandran N JN Brodesser Susanne S Göbel Heike H Becker Jan U JU Benzing Thomas T Schermer Bernhard B Höhne Martin M Burst Volker V Saez-Rodriguez Julio J Huesgen Pitter F PF Müller Roman-Ulrich RU Rinschen Markus M MM

Kidney international 20181203 2

Acute kidney injury (AKI) leads to significant morbidity and mortality; unfortunately, strategies to prevent or treat AKI are lacking. In recent years, several preconditioning protocols have been shown to be effective in inducing organ protection in rodent models. Here, we characterized two of these interventions-caloric restriction and hypoxic preconditioning-in a mouse model of cisplatin-induced AKI and investigated the underlying mechanisms by acquisition of multi-layered omic data (transcrip ...[more]

PMID: 30522767

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