Dataset Information

Breast Cancer Metastasis Organotropism

ABSTRACT: Mass-spectrum profiling of secretory proteins of breast cancer cells with varied capabilities of metastasis to lungs and bone.

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Guohong Hu

LAB HEAD: Guohong Hu

PROVIDER: PXD007227 | Pride | 2017-10-04

REPOSITORIES: pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20100115_YL_SCP4.RAW	Raw
	Secretome_results.xls	Xls

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Publications

Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1.

Zhuang Xueqian X Zhang Hao H Li Xiaoyan X Li Xiaoxun X Cong Min M Peng Fangli F Yu Jingyi J Zhang Xue X Yang Qifeng Q Hu Guohong G

Nature cell biology 20170911 10

Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and neutrophil recruitment in lung metastases by antagonizing cancer cell non-canonical WNT/PCP-RAC1-JNK signalling. In the lungs, DKK1 also inhibits WNT/Ca<sup>2+</sup>-CaMKII-NF-κB sign ...[more]

PMID: 28892080

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