Proteomics

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FFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer

ABSTRACT: Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neoplastic islands proteins and from stroma tumor as correlated to clinicopathological data including lymphonode status and recurrence.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tongue

DISEASE(S): Oral Squamous Cell Carcinoma

SUBMITTER: Adriana Franco Paes Leme  

LAB HEAD: Adriana Franco Paes Leme Squina

PROVIDER: PXD007232 | Pride | 2018-09-10

REPOSITORIES: Pride

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Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer.

Carnielli Carolina Moretto CM   Macedo Carolina Carneiro Soares CCS   De Rossi Tatiane T   Granato Daniela Campos DC   Rivera César C   Domingues Romênia Ramos RR   Pauletti Bianca Alves BA   Yokoo Sami S   Heberle Henry H   Busso-Lopes Ariane Fidelis AF   Cervigne Nilva Karla NK   Sawazaki-Calone Iris I   Meirelles Gabriela Vaz GV   Marchi Fábio Albuquerque FA   Telles Guilherme Pimentel GP   Minghim Rosane R   Ribeiro Ana Carolina Prado ACP   Brandão Thaís Bianca TB   de Castro Gilberto G   González-Arriagada Wilfredo Alejandro WA   Gomes Alexandre A   Penteado Fabio F   Santos-Silva Alan Roger AR   Lopes Márcio Ajudarte MA   Rodrigues Priscila Campioni PC   Sundquist Elias E   Salo Tuula T   da Silva Sabrina Daniela SD   Alaoui-Jamali Moulay A MA   Graner Edgard E   Fox Jay W JW   Coletta Ricardo Della RD   Paes Leme Adriana Franco AF  

Nature communications 20180905 1

Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor-node-metastasis prognosis classification. Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differen  ...[more]

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