Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Francien Talens
LAB HEAD: Marcel A T M van Vugt
PROVIDER: PXD007253 | Pride | 2018-12-19
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 6 |
Heijink Anne Margriet AM Talens Francien F Jae Lucas T LT van Gijn Stephanie E SE Fehrmann Rudolf S N RSN Brummelkamp Thijn R TR van Vugt Marcel A T M MATM
Nature communications 20190109 1
Loss of BRCA2 affects genome stability and is deleterious for cellular survival. Using a genome-wide genetic screen in near-haploid KBM-7 cells, we show that tumor necrosis factor-alpha (TNFα) signaling is a determinant of cell survival upon BRCA2 inactivation. Specifically, inactivation of the TNF receptor (TNFR1) or its downstream effector SAM68 rescues cell death induced by BRCA2 inactivation. BRCA2 inactivation leads to pro-inflammatory cytokine production, including TNFα, and increases sens ...[more]