Proteomics

Dataset Information

0

Plasmodium falciparum PHIL1 LC-MS/MS


ABSTRACT: Plasmodium falciparum sexual-stage parasites expressing an epitope-tagged PHIL1 protein were analysed by co-IP and subsequent LC-MS/MS as

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: Emma McHugh  

LAB HEAD: Leann Tilley

PROVIDER: PXD007564 | Pride | 2017-09-28

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
150715_annika_3d71.dat Other
150715_annika_3d71.mgf Mgf
150715_annika_3d71.mzid Mzid
150715_annika_3d71.raw Raw
150715_annika_gfp1.dat Other
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Publications

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development.

Parkyn Schneider Molly M   Liu Boyin B   Glock Philipp P   Suttie Annika A   McHugh Emma E   Andrew Dean D   Batinovic Steven S   Williamson Nicholas N   Hanssen Eric E   McMillan Paul P   Hliscs Marion M   Tilley Leann L   Dixon Matthew W A MWA  

PLoS pathogens 20171006 10


Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the human pathogen, Plasmodium falciparum, adopt a crescent shape. Their dramatic morphogenesis is driven by the assembly of a network of microtubules and an underpinning inner membrane complex (IMC). Using super-resolution optical and electron microscopies we define the ultrastructure of the IMC at different stages of gametocyte development. We characterize two new protein  ...[more]

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