Proteomics

Dataset Information

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Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.


ABSTRACT: This study represents a proteomic resource for HNSCC and SQCLC with quantitative protein expression data for 7800 proteins and provides a proteomic diagnostic signature for classification for undetermined secondary lung tumors in HNSCC patients. By quantitative mass-spectrometry-based proteomics, we characterized a cohort of 63 squamous cell carcinomas of the lung (SQCLC), 49 of the head and neck region (HNSCC) and 51 HNSCC-correlated lung tumors with squamous cell histology that evolved in the course of the disease.

INSTRUMENT(S): Q Exactive HF-X, Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: Kuan-Ting Pan  

LAB HEAD: Thomas Oellerich

PROVIDER: PXD007705 | Pride | 2018-08-06

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
1-Training_set.zip Other
2-Validation_set.zip Other
3-Lung_tumours.zip Other
D_Yepes_010915_120915_FASP_HP10.raw Raw
D_Yepes_010915_120915_FASP_HP16.raw Raw
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Publications

Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.

Bohnenberger Hanibal H   Kaderali Lars L   Ströbel Philipp P   Yepes Diego D   Plessmann Uwe U   Dharia Neekesh V NV   Yao Sha S   Heydt Carina C   Merkelbach-Bruse Sabine S   Emmert Alexander A   Hoffmann Jonatan J   Bodemeyer Julius J   Reuter-Jessen Kirsten K   Lois Anna-Maria AM   Dröge Leif Hendrik LH   Baumeister Philipp P   Walz Christoph C   Biggemann Lorenz L   Walter Roland R   Häupl Björn B   Comoglio Federico F   Pan Kuan-Ting KT   Scheich Sebastian S   Lenz Christof C   Küffer Stefan S   Bremmer Felix F   Kitz Julia J   Sitte Maren M   Beißbarth Tim T   Hinterthaner Marc M   Sebastian Martin M   Lotz Joachim J   Schildhaus Hans-Ulrich HU   Wolff Hendrik H   Danner Bernhard C BC   Brandts Christian C   Büttner Reinhard R   Canis Martin M   Stegmaier Kimberly K   Serve Hubert H   Urlaub Henning H   Oellerich Thomas T  

EMBO molecular medicine 20180901 9


Patients with head-and-neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance of discrimination, reliable diagnostic biomarkers are still lacking. Here, we have characterised a cohort of squamous cell lung (SQCLC) and head-and-neck (HNSCC) carcinomas by quantitative proteomics. In a training cohort, we quantified 4,957 proteins in 44 SQCLC and 30 HNSCC tumours. A total of 518 proteins were found to be differentiall  ...[more]

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