Proteomics

Dataset Information

0

Identification of the covalent binding site of Ibrutinib and 5Z-7-Oxozeaenol to ZAK


ABSTRACT: The goal of this experiment was to identify the reaction site of Ibrutinib and 5Z-7-Oxozeaenol to ZAK by determination of mass shifts according to a covalent modification by the inhibitors using mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD007752 | Pride | 2017-10-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
55831_F1_R2_P0132328A01.raw.gz Raw
55831_F1_R2_P0132329A01.raw.gz Raw
55864_F1_R1_P0135505A01.raw.gz Raw
55865_F1_R1_P0135513A01.raw.gz Raw
F270382.dat Other
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Publications

Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors.

Dittus Lars L   Werner Thilo T   Muelbaier Marcel M   Bantscheff Marcus M  

ACS chemical biology 20170912 10


Chemoproteomics profiling of kinase inhibitors with kinobeads enables the assessment of inhibitor potency and selectivity for endogenously expressed protein kinases in cell lines and tissues. Using a small panel of targeted covalent inhibitors, we demonstrate the importance of measuring covalent target binding in live cells. We present a differential kinobeads profiling strategy for covalent kinase inhibitors where a compound is added either to live cells or to a cell extract that enables the co  ...[more]

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