Dataset Information
Lupus Nephritis is characterized by defective removal of Neutrophil Extracellular Traps that are modified in protein composition and contain specific auto-antigens.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Chiara Lavarello
LAB HEAD: Andrea Petretto
PROVIDER: PXD007754 | Pride | 2019-11-12
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Candiano_F_Net_12_Prot_034.raw | Raw | |||
| Candiano_F_Net_14_NoProt_042.raw | Raw | |||
| Candiano_F_Net_17_NoProt_041.raw | Raw | |||
| Candiano_F_Net_19_Prot_035.raw | Raw | |||
| Candiano_F_Net_1_Prot_030.raw | Raw |
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Publications
Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized αenolase (methionine sulfoxide 93).
Scientific reports 20190528 1
NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myristate acetate (PMA) stimulated neutrophils was analyzed by high-throughput Fusion Orbitrap technology in 16 patients with Systemic Lupus Erythematosus/Lupus nephritis (9 SLE/7 LN) an ...[more]
