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Cytoplasmic Proteomics for Temozolomide Resistance in Glioblastoma

ABSTRACT: TMZ resistance is one of the main reasons why treatment of glioblastoma (GBM) fails. In order to investigate the underlying mechanism associated with TMZ resistance, we conducted a cytoplasmic proteome research of U87 cells treated with TMZ for 1 week. A total of 162 DEPs including 66 up-regulated proteins and 96 down-regulated proteins were identified.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Brain Glioblastoma Multiforme

SUBMITTER: Yawei Liu

LAB HEAD: Yawei, Liu

PROVIDER: PXD007759 | Pride | 2018-10-23

REPOSITORIES: Pride

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			Action	DRS
	P15452_D_ZHI.raw	Raw
	P15452_D_ZHI_151114034033.raw	Raw
	P15452_D_ZHI_151114064020.raw	Raw
	P15452_T_ZHI.raw	Raw
	P15452_T_ZHI_151113094012.raw	Raw

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Publications

Identification of Key Candidate Proteins and Pathways Associated with Temozolomide Resistance in Glioblastoma Based on Subcellular Proteomics and Bioinformatical Analysis.

Yi Guo-Zhong GZ Xiang Wei W Feng Wen-Yan WY Chen Zi-Yang ZY Li Yao-Min YM Deng Sheng-Ze SZ Guo Man-Lan ML Zhao Liang L Sun Xue-Gang XG He Min-Yi MY Qi Song-Tao ST Liu Ya-Wei YW

BioMed research international 20180301

TMZ resistance remains one of the main reasons why treatment of glioblastoma (GBM) fails. In order to investigate the underlying proteins and pathways associated with TMZ resistance, we conducted a cytoplasmic proteome research of U87 cells treated with TMZ for 1 week, followed by differentially expressed proteins (DEPs) screening, KEGG pathway analysis, protein-protein interaction (PPI) network construction, and validation of key candidate proteins in TCGA dataset. A total of 161 DEPs including ...[more]

PMID: 29687002

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