Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Eric Fischer
LAB HEAD: Eric S. Fischer
PROVIDER: PXD007851 | Pride | 2017-11-08
REPOSITORIES: pride
Action | DRS | |||
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tc-d285_f10a_out.tgz | Other | |||
tc-d285_f11a_out.tgz | Other | |||
tc-d285_f12a_out.tgz | Other | |||
tc-d285_f1a_out.tgz | Other | |||
tc-d285_f2a_out.tgz | Other |
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Huang Hai-Tsang HT Dobrovolsky Dennis D Paulk Joshiawa J Yang Guang G Weisberg Ellen L EL Doctor Zainab M ZM Buckley Dennis L DL Cho Joong-Heui JH Ko Eunhwa E Jang Jaebong J Shi Kun K Choi Hwan Geun HG Griffin James D JD Li Ying Y Treon Steven P SP Fischer Eric S ES Bradner James E JE Tan Li L Gray Nathanael S NS
Cell chemical biology 20171109 1
Heterobifunctional molecules that recruit E3 ubiquitin ligases, such as cereblon, for targeted protein degradation represent an emerging pharmacological strategy. A major unanswered question is how generally applicable this strategy is to all protein targets. In this study, we designed a multi-kinase degrader by conjugating a highly promiscuous kinase inhibitor with a cereblon-binding ligand, and used quantitative proteomics to discover 28 kinases, including BTK, PTK2, PTK2B, FLT3, AURKA, AURKB, ...[more]