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Melanoma BRAFV600E induced proteome

ABSTRACT: By analyzing of the changes in proteome mediated by the oncogene BRAFV600E in melanoma cells we provide new insights on the pathways upregulated in these cells and possible new targets for therapy.

OTHER RELATED OMICS DATASETS IN: GSE111891

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skin

SUBMITTER: Francesca Rapino

LAB HEAD: Francesca Rapino

PROVIDER: PXD008010 | Pride | 2018-06-25

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	All.dat	Other
	DataanlysisSILACBRAFV600E.xlsx	Xlsx
	Incorporation.dat	Other
	MSB20763n764SILACBand_01.mzML	Mzml
	MSB20763n764SILACBand_01.raw	Raw

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Publications

Codon-specific translation reprogramming promotes resistance to targeted therapy.

Rapino Francesca F Delaunay Sylvain S Rambow Florian F Zhou Zhaoli Z Tharun Lars L De Tullio Pascal P Sin Olga O Shostak Kateryna K Schmitz Sebastian S Piepers Jolanda J Ghesquière Bart B Karim Latifa L Charloteaux Benoit B Jamart Diane D Florin Alexandra A Lambert Charles C Rorive Andrée A Jerusalem Guy G Leucci Eleonora E Dewaele Michael M Vooijs Marc M Leidel Sebastian A SA Georges Michel M Voz Marianne M Peers Bernard B Büttner Reinhard R Marine Jean-Christophe JC Chariot Alain A Close Pierre P

Nature 20180620 7711

Reprogramming of mRNA translation has a key role in cancer development and drug resistance 1 . However, the molecular mechanisms that are involved in this process remain poorly understood. Wobble tRNA modifications are required for specific codon decoding during translation2,3. Here we show, in humans, that the enzymes that catalyse modifications of wobble uridine 34 (U34) tRNA (U34 enzymes) are key players of the protein synthesis rewiring that is ind ...[more]

PMID: 29925953

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Expression data from murine colon tissue after exposure to 4% DSS for 6 days DSS followed by 4 days of water or 1% L-arginine

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2012-06-26 | E-GEOD-34874 | biostudies-arrayexpress

Analysis of HeLa cells after transfection with miR-1, miR-124 and miR-181.

Project description:Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124, miR-181 versus control transfected HeLa cells. Results were compared to protein down-regulation at 48 hours measured by SILAC-MS. Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124, miR-181 versus control transfected HeLa cells. Results were compared to protein down-regulation at 48 hours measured by SILAC-MS.

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Transcription profiling of human umbilical vein endothelial cells after transfection with the anti-apoptotic protein vFLIP/K13 of human herpesvirus type-8 (HHV-8)

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Transcriptional profiling of PADI4 overexpression and inhibition in mouse embryonic stem cells

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ATAC-seq of HEK293T cell line

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RNA-seq of HEK293T cell line

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G3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress

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