AD Study - A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: 
Vikram Mitra
LAB HEAD: Dr Ian Pike
PROVIDER: PXD008016 | Pride | 2018-12-17
REPOSITORIES: Pride
Publications
A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology.
Marttinen Mikael M Paananen Jussi J Neme Antonio A Mitra Vikram V Takalo Mari M Natunen Teemu T Paldanius Kaisa M A KMA Mäkinen Petra P Bremang Michael M Kurki Mitja I MI Rauramaa Tuomas T Leinonen Ville V Soininen Hilkka H Haapasalo Annakaisa A Pike Ian I Hiltunen Mikko M
Neurobiology of disease 20181215
No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of changes in mRNA, protein, and phosphopeptide expression levels from human temporal cortical samples, with varying degree of AD-related pathology. This approach highlighted fluctuation in synaptic and mitochondrial function as the earliest pathological events in brain samples with ...[more]
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