Dataset Information

Proteomic profiles of INS1 cells

ABSTRACT: In this study, we obtained proteomic profiles of INS1 cells with lipotoxicity and glucolipotoxicity in a time-course fashion.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Rattus (black Rat)

TISSUE(S): Type B Pancreatic Cell

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: JUNJIE HOU

LAB HEAD: TAO XU

PROVIDER: PXD008154 | Pride | 2018-08-14

REPOSITORIES: Pride

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Publications

Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity.

Li Zonghong Z Liu Hongyang H Niu Zhangjing Z Zhong Wen W Xue Miaomiao M Wang Jifeng J Yang Fuquan F Zhou Yue Y Zhou Yifa Y Xu Tao T Hou Junjie J

Molecular & cellular proteomics : MCP 20180806 11

Chronic hyperlipidemia causes the dysfunction of pancreatic β-cells, such as apoptosis and impaired insulin secretion, which are aggravated in the presence of hyperglycemia. The underlying mechanisms, such as endoplasmic reticulum (ER) stress, oxidative stress and metabolic disorders, have been reported before; however, the time sequence of these molecular events is not fully understood. Here, using isobaric labeling-based mass spectrometry, we investigated the dynamic proteomes of INS-1 cells e ...[more]

PMID: 30082485

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