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Proteomic Identification of Interferon-induced Proteins with Tetratricopeptide Repeats (IFITs) as Markers of M1 Macrophage Polarization

ABSTRACT: Proteomic studies of macrophage polarization to pro-inflammatory (M1) or tissue reparative (M2) phenotypes has identified interferon-induced proteins with tetratricopeptide repeats (IFIT1, IFIT2 and IFIT3) as potential biomarkers of inflammatory diseases such as atherosclerosis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ralf Schittenhelm

LAB HEAD: Martin Stone

PROVIDER: PXD008204 | Pride | 2018-03-15

REPOSITORIES: Pride

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			Action	DRS
	CHH20150501_THP-1_CTR_1-1.raw	Raw
	CHH20150501_THP-1_CTR_1-2.raw	Raw
	CHH20150501_THP-1_CTR_1-3.raw	Raw
	CHH20150501_THP-1_CTR_1-4.raw	Raw
	CHH20150501_THP-1_CTR_1-5.raw	Raw

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Publications

Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.

Huang Cheng C Lewis Caitlin C Borg Natalie A NA Canals Meritxell M Diep Henry H Drummond Grant R GR Goode Robert J RJ Schittenhelm Ralf B RB Vinh Antony A Zhu Mingyu M Kemp-Harper Barbara B Kleifeld Oded O Stone Martin J MJ

Journal of proteome research 20180313 4

Macrophages, which accumulate in tissues during inflammation, may be polarized toward pro-inflammatory (M1) or tissue reparative (M2) phenotypes. The balance between these phenotypes can have a substantial influence on the outcome of inflammatory diseases such as atherosclerosis. Improved biomarkers of M1 and M2 macrophages would be beneficial for research, diagnosis, and monitoring the effects of trial therapeutics in such diseases. To identify novel biomarkers, we have characterized the global ...[more]

PMID: 29508616

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