Dataset Information

Global lip mod analysis - Obesity-Induced Protein Carbonylation In Murine Adipose Tissue Regulates The DNA Binding Domain Of Nuclear Zinc-Finger Proteins

ABSTRACT: The project involves global proteomics analysis of HNE and HHE modified proteins in mammalian tissues and cells.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Adipose Tissue Of Abdominal Region, Primary Cell, Adipose Tissue, Subcutaneous Adipose Tissue

SUBMITTER: Yue Chen

LAB HEAD: Yue Chen

PROVIDER: PXD008415 | Pride | 2018-07-16

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MaxquantOutputs.zip	Other
	yuechen_tzhou_Amy_nonhistonePeptideenrichment.raw	Raw
	yuechen_tzhou_Amy_nonhistoneProteinenrichment.raw	Raw
	yuechen_tzhou_amyH2F1.raw	Raw
	yuechen_tzhou_amyH2F1dda_151105142030.raw	Raw

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Publications

Obesity-induced protein carbonylation in murine adipose tissue regulates the DNA-binding domain of nuclear zinc finger proteins.

Hauck Amy K AK Zhou Tong T Hahn Wendy W Petegrosso Raphael R Kuang Rui R Chen Yue Y Bernlohr David A DA

The Journal of biological chemistry 20180716 35

In obesity-linked insulin resistance, oxidative stress in adipocytes leads to lipid peroxidation and subsequent carbonylation of proteins by diffusible lipid electrophiles. Reduction in oxidative stress attenuates protein carbonylation and insulin resistance, suggesting that lipid modification of proteins may play a role in metabolic disease, but the mechanisms remain incompletely understood. Herein, we show that <i>in vivo</i>, diet-induced obesity in mice surprisingly results in preferential c ...[more]

PMID: 30012885

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