Proteomics

Dataset Information

0

Correction of cognitive deficits in mouse models of Down syndrome by pharmacological inhibitor of DYRK1A

ABSTRACT: Down Syndrome (DS) results from the trisomy of human chromosome 21 (HSA21). It is still the most frequent intellectual disability, affecting 1 newborn per 700 births. Among candidate genes explaining intellectual disabilities seen in DS patients, the dual specificity tyrosine-phosphorylation regulated kinase 1A, DYRK1A, is located in the DS critical region of chromosome 21. DYRK1A has become a major screening target for the development of selective and potent pharmacological inhibitors. We here investigated the effects of a relatively selective DYRK1A inhibitor, Leucettine 41 (hereafter L41) in three different trisomic mouse models with increasing genetic complexity, Tg(Dyrk1a), Ts65Dn and Dp1Yey. Leucettines are derived from the marine sponge alkaloid Leucettamine B.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Antigoni Manousopoulou  

LAB HEAD: Spiros D Garbis

PROVIDER: PXD008419 | Pride | 2018-10-17

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
03Sep14_L41_Hipppocampus.mzData Other
18AUG14_L41_CORTEX.mzData Other
22AUG14_L41_CEREBELLUM.mzData Other
MultiConsensus_Cortex_Cerebellumn_Hippocampus.pep.pep.xml Pepxml
Items per page:
1 - 4 of 4
altmetric image

Publications

Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition memory deficits in three DS mouse models with increasing genetic complexity [Tg(<i>Dyrk1a</i>), Ts65Dn, Dp1Yey], all expressing an extra copy of <i>Dyrk1a</i> Overexpressed DYRK1A accumulates in the cytoplasm and at the synapse. Treatment of the three  ...[more]

Similar Datasets

Transcriptomics Rescue of Down syndrome related deficits by Brwd1 copy number restoration in Ts65Dn mice
2022-09-21 | GSE210117 | GEO
Transcriptomics Rescue of Down syndrome related deficits by Brwd1 copy number restoration
2022-09-22 | GSE151255 | GEO
Transcriptomics Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism and late-onset Alzheimer’s disease
2022-07-18 | GSE201290 | GEO
Transcriptomics Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis
2023-11-04 | GSE243702 | GEO
Proteomics Proteome analysis in the TcMAC21 mouse model of Down syndrome
2023-10-23 | PXD044343 | Pride
Transcriptomics Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models (RNA-Seq reanalysis II)
2021-03-17 | GSE149469 | GEO
Transcriptomics Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models (RNA-Seq reanalysis I)
2021-03-17 | GSE149467 | GEO
Transcriptomics Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models (Affymetrix reanalysis)
2021-03-17 | GSE149466 | GEO
Transcriptomics Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models (Ts65Dn)
2021-03-17 | GSE149465 | GEO
Transcriptomics Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models (TgDyrk1a)
2021-03-17 | GSE149464 | GEO