Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Antigoni Manousopoulou
LAB HEAD: Spiros D Garbis
PROVIDER: PXD008419 | Pride | 2018-10-17
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
03Sep14_L41_Hipppocampus.mzData | Other | |||
18AUG14_L41_CORTEX.mzData | Other | |||
22AUG14_L41_CEREBELLUM.mzData | Other | |||
MultiConsensus_Cortex_Cerebellumn_Hippocampus.pep.pep.xml | Pepxml |
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Nguyen Thu Lan TL Duchon Arnaud A Manousopoulou Antigoni A Loaëc Nadège N Villiers Benoît B Pani Guillaume G Karatas Meltem M Mechling Anna E AE Harsan Laura-Adela LA Limanton Emmanuelle E Bazureau Jean-Pierre JP Carreaux François F Garbis Spiros D SD Meijer Laurent L Herault Yann Y
Disease models & mechanisms 20180927 9
Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition memory deficits in three DS mouse models with increasing genetic complexity [Tg(<i>Dyrk1a</i>), Ts65Dn, Dp1Yey], all expressing an extra copy of <i>Dyrk1a</i> Overexpressed DYRK1A accumulates in the cytoplasm and at the synapse. Treatment of the three ...[more]