Dataset Information

Systems toxicology assessment of CHTP1.2 [Liver Data]

ABSTRACT: Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxicology arm of a 90-day rat inhalation study (OECD test guideline 413) to assess the effects of CHTP1.2 aerosol compared with cigarette smoke (CS). Rats were exposed to filtered air (sham), to CHTP1.2 aerosol (at 15, 23 and 50 µg nicotine / L), or to the 3R4F reference cigarette smoke (at 23 µg nicotine / L).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver

SUBMITTER: Bjoern Titz

LAB HEAD: Julia Hoeng

PROVIDER: PXD008423 | Pride | 2018-03-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20170110_S150223__Liv_90d_set10_DR_PS_02.raw	Raw
	20170110_S150223__Liv_90d_set10_DR_PS_15.raw	Raw
	20170110_S150223__Liv_90d_set11_DR_PS_01.raw	Raw
	20170110_S150223__Liv_90d_set11_DR_PS_17.raw	Raw
	20170110_S150223__Liv_90d_set12_DR_PS_05.raw	Raw

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Publications

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Titz Bjoern B Kogel Ulrike U Martin Florian F Schlage Walter K WK Xiang Yang Y Nury Catherine C Dijon Sophie S Baumer Karine K Peric Dariusz D Bornand David D Dulize Remi R Phillips Blaine B Leroy Patrice P Vuillaume Gregory G Lebrun Stefan S Elamin Ashraf A Guedj Emmanuel E Trivedi Keyur K Ivanov Nikolai V NV Vanscheeuwijck Patrick P Peitsch Manuel C MC Hoeng Julia J

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180313

Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. Here, we report the results from the systems toxicology arm of a 90-day rat inhalation study (OECD test guideline 413) to assess the effects of CHTP1.2 aerosol compared with cigarette smoke (CS). Transcriptomics, proteomics, and lipidomics analyses com ...[more]

PMID: 29545142

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