Dataset Information

2017 gddy+M1

ABSTRACT: This project is to investgate the effect of M1 compound in gddy mice

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

DISEASE(S): Iga Glomerulonephritis

SUBMITTER: Lichieh Julie Chu

LAB HEAD: Ann Chen

PROVIDER: PXD008431 | Pride | 2020-04-02

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20161225-JdolY30ug_20ug-s01.raw	Raw
	20161225-JdolY30ug_20ug-s02.raw	Raw
	20161225-JdolY30ug_20ug-s03.raw	Raw
	20161225-JdolY30ug_20ug-s04.raw	Raw
	20161225-JdolY30ug_20ug-s05.raw	Raw

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Publications

IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-κB/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1.

Wu Chung-Yao CY Hua Kuo-Feng KF Hsu Wan-Han WH Suzuki Yusuke Y Chu Lichieh Julie LJ Lee Yu-Chieh YC Takahata Akiko A Lee Sheau-Long SL Wu Chia-Chao CC Nikolic-Paterson David J DJ Ka Shuk-Man SM Chen Ann A

Journal of immunology (Baltimore, Md. : 1950) 20200601 1

IgA nephropathy (IgAN), the most common primary glomerular disorder, has a relatively poor prognosis yet lacks a pathogenesis-based treatment. Compound K (CK) is a major absorbable intestinal bacterial metabolite of ginsenosides, which are bioactive components of ginseng. The present study revealed promising therapeutic effects of CK in two complementary IgAN models: a passively induced one developed by repeated injections of IgA immune complexes and a spontaneously occurring model of spontaneou ...[more]

PMID: 32482710

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