Dataset Information

Predicting response to chemotherapy in rectal cancer

ABSTRACT: Neoadjuvant chemoradiotherapy (CRT) is used in locally advanced rectal cancer when tumours threaten the circumferential resection margin. A variable response to treatment remains, notwithstanding potentially significant morbidity, and no clinically routinely used predictive biomarkers guide decision making. This experimental study aimed to identify significantly differentially expressed proteins between patients responding or not to CRT, using novel temporal proteomic profiling, and to validate any proteins of interest.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Rectum, Rectum Smooth Muscle Tissue, Epithelial Cell, Epithelium Of Rectum, Fibroblast, Macrophage

DISEASE(S): Rectum Cancer

SUBMITTER: Rosalind Jenkins

LAB HEAD: Rosalind Elspeth Jenkins

PROVIDER: PXD008436 | Pride | 2018-03-12

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	PSiTRAQ1BMGFPeaklist.mgf	Mgf
	PSiTRAQ1BpeptideSEARCH.xlsx	Xlsx
	PSiTRAQ1BproteinQUANT.xlsx	Xlsx
	PSiTRAQ1BproteinSEARCH.xlsx	Xlsx
	PSiTRAQ1BrectalcancerCEX39-40270713.wiff	Wiff

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Publications

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.

Bowden D L DL Sutton P A PA Wall M A MA Jithesh P V PV Jenkins R E RE Palmer D H DH Goldring C E CE Parsons J L JL Park B K BK Kitteringham N R NR Vimalachandran D D

Journal of proteomics 20180306

<h4>Background</h4>Neoadjuvant chemoradiotherapy (CRT) is used in locally advanced rectal cancer when tumours threaten the circumferential resection margin, with varying response to treatment. This experimental study aimed to identify significantly differentially expressed proteins between patients responding and not responding to CRT, and to validate any proteins of interest.<h4>Methods</h4>Mass spectrometry (with isobaric tagging for relative quantification) analysis of rectal cancers pre- and ...[more]

PMID: 29518574

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