Proteomics

Dataset Information

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Triatoma dimidiata salivary glands LC-MSMS

ABSTRACT: The reduviid bug Triatoma dimidiata is an important Chagas disease vector widely distributed along Central America. This insect has great capability for domestic adaptation as the majority of specimens caught inside human dwellings or in peridomestic areas in Central America fed human blood. Within this context, exploring the salivary compounds that overcome host haemostatic and immune responses to assist blood-feeding is of great scientific interest. Our aim is to provide a deeper insight into T. dimidiata salivary gland molecules that may contribute to its haematophagic habit. We realized T. dimidiata salivary transcriptomic analysis and complemented it through proteomics, disclosing the set complexity of 119 secreted proteins. The large-scale approach used enriches the pharmacologically active molecules database and improves our knowledge about the complexity of salivary compounds from haematophagous vectors and their biological interactions.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Triatoma Dimidiata

TISSUE(S): Saliva

SUBMITTER: Carla Araújo  

LAB HEAD: Jaime Martins de Santana

PROVIDER: PXD008510 | Pride | 2018-01-04

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Tdim-y.mgf Mgf
Tdim-y.msf Msf
Tdim-y.pdResult Other
Tdim-y1-2.raw Raw
Tdim-y1-3.raw Raw
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Publications

Triatoma dimidiata, a Chagas disease vector widely distributed along Central America, has great capability for domestic adaptation as the majority of specimens caught inside human dwellings or in peridomestic areas fed human blood. Exploring the salivary compounds that overcome host haemostatic and immune responses is of great scientific interest. Here, we provide a deeper insight into its salivary gland molecules. We used high-throughput RNA sequencing to examine in depth the T. dimidiata saliv  ...[more]

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