Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Cell Line Cell
SUBMITTER: Timothy Bergmann
LAB HEAD: Maurizio Molinari
PROVIDER: PXD008529 | Pride | 2018-02-16
REPOSITORIES: Pride
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Bergmann Timothy J TJ Fregno Ilaria I Fumagalli Fiorenza F Rinaldi Andrea A Bertoni Francesco F Boersema Paul J PJ Picotti Paola P Molinari Maurizio M
The Journal of biological chemistry 20180216 15
The stress sensors ATF6, IRE1, and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to re-establish proteostasis. UPR have been extensively investigated in cells exposed to chemicals that activate ER stress sensors by perturbing calcium, <i>N</i>-glycans, or redox homeostasis. Cell responses to variations in luminal load with unfolded proteins are, ...[more]