Proteomics

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Comparison of brain and hippocampal majority proteomes from MAP6 KO mice submitted or not to electroconvulsive stimulations


ABSTRACT: For major depression, the non-drug therapy Electroconvulsive therapy (ECT) treatment is highly effective and fast-acting. Despite a large and long-standing clinical use, the neurobiological mechanisms underlining ECT curative action are still poorly understood. Thanks to a genetic animal model that constitutively exhibit behavioural and biological features relevant to some aspects of major depressive disorder, here we analyse the behavioural and biological consequences of electroconvulsive stimulations (ECS), the animal model of ECT. We found that a classical ECS treatment, with 10 stimulation over 2 weeks period, has a beneficial effect on constitutive behavioural defects. We therefore compared brain and hippocampal majority proteomes from MAP6 KO mice submitted or not to electroconvulsive stimulations.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Hippocampus

SUBMITTER: Yohann Couté  

LAB HEAD: Virginie Brun

PROVIDER: PXD008543 | Pride | 2019-03-12

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Brain_experimentalDesignTemplate.txt Txt
Brain_txt.zip Other
Hippocampus_experimentalDesignTemplate.txt Txt
Hippocampus_txt.zip Other
VELOS25722.raw Raw
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Publications


<h4>Background</h4>Severe and medication-resistant psychiatric diseases, such as major depressive disorder, bipolar disorder or schizophrenia, can be effectively and rapidly treated by electroconvulsive therapy (ECT). Despite extensive long-standing clinical use, the neurobiological mechanisms underlying the curative action of ECT remain incompletely understood.<h4>Objective</h4>Unravel biological basis of electroconvulsive stimulation (ECS) efficacy, the animal equivalent of ECT.<h4>Methods</h4  ...[more]

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