Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brown Adipose Tissue
SUBMITTER: Danielle Swaney
LAB HEAD: Danielle Swaney
PROVIDER: PXD008599 | Pride | 2018-07-12
REPOSITORIES: Pride
Action | DRS | |||
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evidence.txt | Txt | |||
experimentalDesignTemplate.txt | Txt | |||
keys-v6Fixed.txt | Txt | |||
proteinGroups.txt | Txt | |||
qx003245.raw | Raw |
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Cell metabolism 20180301 3
Brown adipose tissue (BAT) thermogenesis is critical for thermoregulation and contributes to total energy expenditure. However, whether BAT has non-thermogenic functions is largely unknown. Here, we describe that BAT-specific liver kinase b1 knockout (Lkb1<sup>BKO</sup>) mice exhibited impaired BAT mitochondrial respiration and thermogenesis but reduced adiposity and liver triglyceride accumulation under high-fat-diet feeding at room temperature. Importantly, these metabolic benefits were also p ...[more]