Proteomics

Dataset Information

0

Multiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG in T-cells


ABSTRACT: Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins in resting T-cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD008635 | Pride | 2018-05-02

REPOSITORIES: Pride

Dataset's files

Source:
altmetric image

Publications


Protein degradation plays important roles in biological processes and is tightly regulated. Further, targeted proteolysis is an emerging research tool and therapeutic strategy. However, proteome-wide technologies to investigate the causes and consequences of protein degradation in biological systems are lacking. We developed "multiplexed proteome dynamics profiling" (mPDP), a mass-spectrometry-based approach combining dynamic-SILAC labeling with isobaric mass tagging for multiplexed analysis of  ...[more]

Similar Datasets

2018-05-02 | PXD008634 | Pride
2018-04-05 | PXD008633 | Pride
2018-05-02 | PXD008627 | Pride
2013-01-10 | E-GEOD-38972 | biostudies-arrayexpress
2022-12-20 | PXD033459 | Pride
2010-10-11 | E-GEOD-23209 | biostudies-arrayexpress
2015-03-14 | GSE66867 | GEO
2019-05-17 | GSE129944 | GEO
2017-01-11 | GSE93384 | GEO
2010-10-12 | GSE23209 | GEO