Proteomics

Dataset Information

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Multiplexed proteome dynamics profiling of Estradiol and SERMs

ABSTRACT: Investigation of proteostatic effects of Estradiol, raloxifen and GW7604 in MCF7 cells.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Mammary Gland Epithelial Cell

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD008636 | Pride | 2018-05-02

REPOSITORIES: Pride

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Publications

Protein degradation plays important roles in biological processes and is tightly regulated. Further, targeted proteolysis is an emerging research tool and therapeutic strategy. However, proteome-wide technologies to investigate the causes and consequences of protein degradation in biological systems are lacking. We developed "multiplexed proteome dynamics profiling" (mPDP), a mass-spectrometry-based approach combining dynamic-SILAC labeling with isobaric mass tagging for multiplexed analysis of  ...[more]

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