Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA433856
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Early Embryonic Cell
DISEASE(S): Disease Free
SUBMITTER: Guilian Xu
LAB HEAD: David R. Borchelt
PROVIDER: PXD008896 | Pride | 2018-08-03
REPOSITORIES: Pride
Iradi M Carolina Gallego MCG Triplett Judy C JC Thomas James D JD Davila Rachel R Crown Anthony M AM Brown Hilda H Lewis Jada J Swanson Maurice S MS Xu Guilian G Rodriguez-Lebron Edgardo E Borchelt David R DR
Scientific reports 20180306 1
To understand how mutations in Matrin 3 (MATR3) cause amyotrophic lateral sclerosis (ALS) and distal myopathy, we used transcriptome and interactome analysis, coupled with microscopy. Over-expression of wild-type (WT) or F115C mutant MATR3 had little impact on gene expression in neuroglia cells. Only 23 genes, expressed at levels of >100 transcripts showed ≥1.6-fold changes in expression by transfection with WT or mutant MATR3:YFP vectors. We identified ~123 proteins that bound MATR3, with prote ...[more]