Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Canis Familiaris (dog) (canis Lupus Familiaris)
TISSUE(S): Cell Culture
DISEASE(S): Osteosarcoma
SUBMITTER: Zifeng Song
LAB HEAD: Claudia S. Maier
PROVIDER: PXD008986 | Pride | 2020-05-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Peak_list.mgf | Mgf | |||
Peak_list.pride.mgf.gz | Mgf | |||
UniCanFa_070514.fasta | Fasta | |||
zfs_020816_Glo_hh1_1.raw | Raw | |||
zfs_020816_Glo_hh1_2.raw | Raw |
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Scientific reports 20200120 1
Osteosarcoma (OS) is the most common bone cancer in children and young adults. Solid tumors are characterized by intratumoral hypoxia, and hypoxic cells are associated with the transformation to aggressive phenotype and metastasis. The proteome needed to support an aggressive osteosarcoma cell phenotype remains largely undefined. To link metastatic propensity to a hypoxia-induced proteotype, we compared the protein profiles of two isogenic canine OS cell lines, POS (low metastatic) and HMPOS (hi ...[more]