Proteomics

Dataset Information

0

HIV/HCV co-infection proteomics


ABSTRACT: Hepatic complications of HCV infection, including fibrosis and cirrhosis are accelerated in HIV-infected individuals. Although liver biopsy remains the gold standard for staging HCV-associated liver disease, this test can result in serious complications and is subject to sampling error. These challenges have prompted a search for non-invasive methods for liver fibrosis staging. To this end, we compared serum proteome profiles at different stages of fibrosis in HIV/HCV co- and HCV mono-infected patients using SELDI-TOF MS.

INSTRUMENT(S): 4800 Proteomics Analyzer

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Hepatitis C

SUBMITTER: Momar Ndao  

LAB HEAD: Momar Ndao

PROVIDER: PXD009007 | Pride | 2018-04-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
1171008840_spotA_1.4.xml Xml
1171008840_spotA_1.4_1.xml Xml
1171008840_spotA_3.4.xml Xml
1171008840_spotA_3.4_1.xml Xml
1171008840_spotB_1.4.xml Xml
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Publications

Proteomic fingerprinting in HIV/HCV co-infection reveals serum biomarkers for the diagnosis of fibrosis staging.

Golizeh Makan M   Melendez-Pena Carlos E CE   Ward Brian J BJ   Saeed Sahar S   Santamaria Cynthia C   Conway Brian B   Cooper Curtis C   Klein Marina B MB   Ndao Momar M  

PloS one 20180402 4


<h4>Background</h4>Hepatic complications of hepatitis C virus (HCV), including fibrosis and cirrhosis are accelerated in human immunodeficiency virus (HIV)-infected individuals. Although, liver biopsy remains the gold standard for staging HCV-associated liver disease, this test can result in serious complications and is subject to sampling errors. These challenges have prompted a search for non-invasive methods for liver fibrosis staging. To this end, we compared serum proteome profiles at diffe  ...[more]

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