Dataset Information

Rat serum exosomes after restriction stress

ABSTRACT: The project investigates the occurrence of brain derived proteins as biomarkers for restriction oder immobilisations stress.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Blood Cell, Blood Plasma

DISEASE(S): Acute Stress Disorder

SUBMITTER: Thilo Kaehne

LAB HEAD: Prof. Dr. Thilo Kaehne

PROVIDER: PXD009085 | Pride | 2018-12-21

REPOSITORIES: pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Chrisobal_Exosomes_1D_Area1.mgf	Mgf
	Chrisobal_Exosomes_1D_Area1.mzid	Mzid
	Chrisobal_Exosomes_1D_Area1.raw	Raw
	Chrisobal_Exosomes_1D_Area10.mgf	Mgf
	Chrisobal_Exosomes_1D_Area10.mzid	Mzid

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Publications

Small Extracellular Vesicles in Rat Serum Contain Astrocyte-Derived Protein Biomarkers of Repetitive Stress.

Gómez-Molina Cristóbal C Sandoval Mauricio M Henzi Roberto R Ramírez Juan Pablo JP Varas-Godoy Manuel M Luarte Alejandro A Lafourcade Carlos Andres CA Lopez-Verrilli Alejandra A Smalla Karl-Heinz KH Kaehne Thilo T Wyneken Ursula U

The international journal of neuropsychopharmacology 20190301 3

<h4>Background</h4>Stress precipitates mood disorders, characterized by a range of symptoms present in different combinations, suggesting the existence of disease subtypes. Using an animal model, we previously described that repetitive stress via restraint or immobilization induced depressive-like behaviors in rats that were differentially reverted by a serotonin- or noradrenaline-based antidepressant drug, indicating that different neurobiological mechanisms may be involved. The forebrain astro ...[more]

PMID: 30535257

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