Proteomics

Dataset Information

0

PPARgamma regulates a cell-to-cell communication program in human methastatic melanoma cells


ABSTRACT: We mapped the proteins secreted by A375 melanoma cells in the presence or absence of the PPARagonist rosiglitazone.

INSTRUMENT(S): Orbitrap Fusion, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Melanocyte, Skin

DISEASE(S): Melanoma

SUBMITTER: Manfredo Quadroni  

LAB HEAD: Liliane Michalik

PROVIDER: PXD009108 | Pride | 2019-02-18

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20160526_Pich_8462_140min_2ul.raw Raw
20160526_Pich_8463_140min_2ul.raw Raw
20160706_Pich_8541_140min_2ul.raw Raw
20160706_Pich_8542_140min_2ul.raw Raw
20160819_Pich_8609_140min_2ul.raw Raw
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Publications

Induction of Paracrine Signaling in Metastatic Melanoma Cells by PPARγ Agonist Rosiglitazone Activates Stromal Cells and Enhances Tumor Growth.

Pich Christine C   Meylan Patrick P   Mastelic-Gavillet Beatris B   Nguyen Thanh Nhan TN   Loyon Romain R   Trang Bao Khanh BK   Moser Hélène H   Moret Catherine C   Goepfert Christine C   Hafner Jürg J   Levesque Mitchell P MP   Romero Pedro P   Jandus Camilla C   Michalik Liliane L  

Cancer research 20180905 22


In addition to improving insulin sensitivity in type 2 diabetes, the thiazolidinedione family of compounds and the pharmacologic activation of their best-characterized target PPARγ have been proposed as a therapeutic option for cancer treatment. In this study, we reveal a new mode of action for the thiazolidinedione rosiglitazone that can contribute to tumorigenesis. Rosiglitazone activated a tumorigenic paracrine communication program in a subset of human melanoma cells that involves the secret  ...[more]

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