Dataset Information

Secretome of trophoblast organoids

ABSTRACT: Characterisation of the secretome of placental organoids using Liquid Chromatography and Mass Spectrometry by performing solid phase extraction of the supernatants, followed by tryptic digestion.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Trophoblast

SUBMITTER: Richard Kay

LAB HEAD: Ashley Moffett

PROVIDER: PXD009118 | Pride | 2018-11-29

REPOSITORIES: Pride

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Publications

Trophoblast organoids as a model for maternal-fetal interactions during human placentation.

Turco Margherita Y MY Gardner Lucy L Kay Richard G RG Hamilton Russell S RS Prater Malwina M Hollinshead Michael S MS McWhinnie Alasdair A Esposito Laura L Fernando Ridma R Skelton Helen H Reimann Frank F Gribble Fiona M FM Sharkey Andrew A Marsh Steven G E SGE O'Rahilly Stephen S Hemberger Myriam M Burton Graham J GJ Moffett Ashley A

Nature 20181128 7735

The placenta is the extraembryonic organ that supports the fetus during intrauterine life. Although placental dysfunction results in major disorders of pregnancy with immediate and lifelong consequences for the mother and child, our knowledge of the human placenta is limited owing to a lack of functional experimental models<sup>1</sup>. After implantation, the trophectoderm of the blastocyst rapidly proliferates and generates the trophoblast, the unique cell type of the placenta. In vivo, prolif ...[more]

PMID: 30487605

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