Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Liver
SUBMITTER: Paul Grimsrud
LAB HEAD: Christopher B. Newgard
PROVIDER: PXD009122 | Pride | 2018-05-18
REPOSITORIES: pride
Items per page: 1 - 5 of 44 |
Cell metabolism 20180517 6
Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulates branched-chain ketoacid dehydrogenase (BCKDH), the committed step of BCAA catabolism, lowers circulating BCAA, reduces hepatic steatosis, and improves glucose tolerance in the absence of weight loss in Zucker fatty rats. Phosphoproteom ...[more]