Neuro-2a drug treatment iTRAQ - A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture
SUBMITTER: 
Yumei Liao
LAB HEAD: Lei Shi
PROVIDER: PXD009180 | Pride | 2018-10-19
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Liao_peptide.xml | Xml | |||
| Liao_protein.xml | Xml | |||
| Raw1.raw | Raw | |||
| Raw10.raw | Raw | |||
| Raw2.raw | Raw |
Items per page: 5 1 - 5 of 13 |
Publications
A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors.
Liao Yumei Y Zhuang Xiaoji X Huang Xiaojie X Peng Yinghui Y Ma Xuanyue X Huang Zhi-Xing ZX Liu Feng F Xu Junyu J Wang Ying Y Chen Wei-Min WM Ye Wen-Cai WC Shi Lei L
Frontiers in pharmacology 20180405
Developing therapeutic approaches that target neuronal differentiation will be greatly beneficial for the regeneration of neurons and synaptic networks in neurological diseases. Protein synthesis (mRNA translation) has recently been shown to regulate neurogenesis of neural stem/progenitor cells (NSPCs). However, it has remained unknown whether engineering translational machinery is a valid approach for manipulating neuronal differentiation. The present study identifies that a bivalent securinine ...[more]
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